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Leukemia Cells in Fat Tissue Omaha NE

Leukemia cells can hide in fat tissue to evade chemotherapy, which may explain why obese children with leukemia are more likely to develop chemotherapy resistance and have higher relapse rates, researchers say.

Jason Michael Johanning, MD
(402) 559-5326
983280 Nebraska Medical Ctr
Omaha, NE
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Male
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Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1994

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Gernon M Longo
(402) 559-9800
988095 Nebraska Medical Ctr
Omaha, NE
Specialty
Vascular Surgery

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Bernard Timothy Baxter, MD
(402) 393-6624
8111 Dodge St
Omaha, NE
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Medical School: Univ Of Co Sch Of Med, Denver Co 80262
Graduation Year: 1982

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Tammy Kauzlarich Ramos
(402) 390-6601
9202 W Dodge Rd
Omaha, NE
Specialty
Vascular Surgery

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Richard D Schultz, MD, FACC
(402) 397-0823
1629 N 102nd St
Omaha, NE
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Cardiology, Vascular Surgery, Thoracic Surgery
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Male
Education
Graduation Year: 2007

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Thomas G Lynch, MD
(402) 559-9549
983280 Nebraska Medical Ctr
Omaha, NE
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Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1973

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Scott P Wattenhofer, MD
(402) 393-6624
8111 Dodge St
Omaha, NE
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Medical School: Univ Of Sd Sch Of Med, Vermillion Sd, 57069
Graduation Year: 1984

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Thomas H Webb
(402) 399-9990
9850 Nicholas St
Omaha, NE
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Vascular Surgery

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Eugene Alan Waltke, MD
(402) 393-6624
8111 Dodge St
Omaha, NE
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Medical School: Univ Of Ne Coll Of Med, Omaha Ne 68198
Graduation Year: 1978
Hospital
Hospital: Nebraska Methodist Hospital, Omaha, Ne; Alegent Health Immanuel Med Ct, Omaha, Ne; University Health Center, Lincoln, Ne
Group Practice: Cardiothoracic & Vascular Surg

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Tammy K Ramos, MD
(402) 390-6601
9202 W Dodge Rd Ste 305
Omaha, NE
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Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1985

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Leukemia Cells in Fat Tissue

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TUESDAY, Sept. 22 (HealthDay News) -- Leukemia cells can hide in fat tissue to evade chemotherapy, which may explain why obese children with leukemia are more likely to develop chemotherapy resistance and have higher relapse rates, researchers say.

A previous study found that obese children with leukemia are 50 percent more likely to relapse than lean children.

In this new study, researchers observed that obese mice with leukemia had higher relapse rates than lean mice after they were treated with the first-line chemotherapy drug vincristine. In the mice that relapsed, leukemia cells were found to be hiding in fat tissue during chemotherapy.

"We were surprised to find leukemia cells in the fat tissue," lead researcher Dr. Steven D. Mittelman, the fellowship research director with the Division of Endocrinology at Children's Hospital Los Angeles, and assistant professor of pediatrics, physiology and biophysics at the Keck School of Medicine, University of Southern California, said in a news release from the American Association for Cancer Research.

He and his colleagues also found that four chemotherapy drugs used in children -- vincristine, nilotinib, daunorubicin and dexamethasone -- all worked less effectively in culture when fat cells were nearby.

The study appears online Sept. 22 in the journal Cancer Research.

Mittelman said further research is needed to determine how body fat affects chemotherapy.

The study findings offer "striking experimental support for the clinical observations that obesity is associated with poor prognosis in multiple cancers," Dr. David Hockenbery, a member of the Fred Hutchinson Cancer Research Center and a professor of internal medicine at the University of Washington, said in the news release.

More information

The U.S. National Cancer Institute has more about obesity and cancer.

SOURCE: American Association for Cancer Research, news release, Sept. 22, 2009

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