Nicotine Helping Spur 'Prediabetes' Lincoln NE

The nicotine in cigarette smoke may promote insulin resistance and lead to a condition known as prediabetes, new research in Lincoln shows.

Krynn Keller Buckley
(402) 483-2886
1500 S 48th St
Lincoln, NE
Specialty
Reproductive Endocrinology

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Brenda Troutman Bell, MD
(402) 489-3383
1919 S 40th St Ste 207
Lincoln, NE
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Endocrinology, Diabetes, & Metabolism
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Medical School: Uniformed Services Univ Of The Hlth Sci, Bethesda Md 20814
Graduation Year: 1986

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Jalal Souhil Nafach, MD
(402) 437-0660
2355 Superior St Ste 101
Lincoln, NE
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Endocrinology, Diabetes, & Metabolism
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Male
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Medical School: Univ Of Damascus, Fac Of Med, Damascus, Syria
Graduation Year: 1996

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Sudah Shaheeb, MD
(402) 878-2428
Walthill, NE
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Endocrinology, Diabetes, & Metabolism
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Male
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Medical School: Univ Of Melbourne, Fac Of Med, Parkville, Vic, Australia
Graduation Year: 1981

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Carolyn Maud Doherty
(402) 354-5210
8111 Dodge St
Omaha, NE
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Obstetrics & Gynecology, Reproductive Endocrinology

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Nicolle M Mahoney
(402) 483-2886
1500 S 48th St
Lincoln, NE
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Sarah A Cada
(402) 483-2886
1500 S 48th St
Lincoln, NE
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DeAnna L Hutchins
(402) 483-2886
1500 S 48th St
Lincoln, NE
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Reproductive Endocrinology

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Jennifer Lynn Larsen, MD
(402) 559-4837
983020 Nebraska Medical Ctr
Omaha, NE
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Endocrinology, Diabetes, & Metabolism
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Female
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Medical School: Univ Of Ia Coll Of Med, Iowa City Ia 52242
Graduation Year: 1979

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Sajeev Balakrishnan, MD
(701) 232-3241
Omaha, NE
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Endocrinology, Diabetes, & Metabolism
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Male
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Medical School: Tirunelveli Med Coll, Madurai Univ, Tirunelveli, Tn, India
Graduation Year: 1986

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Nicotine Helping Spur 'Prediabetes'

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THURSDAY, June 11 (HealthDay News) -- The nicotine in cigarette smoke may promote insulin resistance and lead to a condition known as prediabetes, new research shows.

The finding, to be outlined Thursday at the Endocrine Society's annual meeting in Washington, D.C., could explain why smokers are at higher risk for diabetes. The same team of researchers was able to partially reverse nicotine's effect on insulin in mice by giving the rodents the nicotine-blunting drug mecamylamine.

In a society news release, study author Dr. Theodore Friedman, chief of the division of endocrinology, metabolism and molecular medicine at Charles R. Drew University of Medicine and Science in Los Angeles, noted that smokers tend to face a higher diabetes risk, even though "smoking causes weight loss, which should protect against heart disease."

But prior studies have shown smokers to be more insulin-resistant, which leads to higher blood-sugar levels. Some studies had suggested that the key factor at work was nicotine's effect on the stress hormone cortisol, since, as Friedman said, "cortisol excess is known to induce insulin resistance."

In their study, the team gave adult mice twice-daily injections of nicotine for 14 days. The mice displayed higher levels of cortisol in the blood. They also ate less and lost weight compared to mice that did not receive the shots but nonetheless developed insulin resistance and prediabetes.

Treating the mice with the nicotine-agonist drug mecamylamine blocked this process somewhat, the researchers noted.

"Our results suggest that reducing tissue glucocorticoid levels or decreasing insulin resistance may reduce the heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be drugs to specifically block the effect of nicotine on glucocorticoids [such as cortisol] and insulin resistance."

More information

There's more on prediabetes at the American Diabetes Association.

SOURCE: The Endocrine Society, news release, June 11, 2009

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