» » »

Nicotine Helping Spur 'Prediabetes' Omaha NE

The nicotine in cigarette smoke may promote insulin resistance and lead to a condition known as prediabetes, new research in Omaha shows.

Cyrus V Desouza, MD
(402) 559-6205
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Male
Education
Medical School: St John'S Med Coll, Bangalore Univ, Bangalore, Karnataka, India
Graduation Year: 1996

Data Provided by:
Amy Schlichtemeier Neumeister, MD
(402) 559-8700
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
James Lane, MD
(402) 559-6205
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Male
Education
Medical School: Univ Of Mo-Kansas City Sch Of Med, Kansas City Mo 64108
Graduation Year: 1984

Data Provided by:
Whitney Sears Goldner, MD
(402) 559-6205
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Female
Education
Medical School: Univ Of Ne Coll Of Med, Omaha Ne 68198
Graduation Year: 1998

Data Provided by:
Lynn Renee Mack-Shipman, MD
(402) 559-6205
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Jennifer Lynn Larsen, MD
(402) 559-4837
983020 Nebraska Medical Ctr
Omaha, NE
Specialties
Endocrinology, Diabetes, & Metabolism
Gender
Female
Education
Medical School: Univ Of Ia Coll Of Med, Iowa City Ia 52242
Graduation Year: 1979

Data Provided by:
Richard Eugene Lutz, MD
(402) 559-6800
985450 Nebraska Medical Ctr
Omaha, NE
Specialties
Pediatrics, Pediatric Endocrinology
Gender
Male
Education
Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1984

Data Provided by:
Deepika Santosh Reddy
(402) 559-4000
983020 Nebraska Medical Ctr
Omaha, NE
Specialty
Endocrinology, Diabetes & Metabolism

Data Provided by:
Kevin Patrick Corley, MD
(402) 559-7466
985390 Nebraska Medical Ctr
Omaha, NE
Specialties
Pediatrics, Pediatric Endocrinology
Gender
Male
Education
Medical School: Univ Of Il Coll Of Med, Chicago Il 60680
Graduation Year: 1972

Data Provided by:
Kevin P Corley
(402) 559-9800
988095 Nebraska Medical Ctr
Omaha, NE
Specialty
Endocrinology, Pediatric Endocrinology

Data Provided by:
Data Provided by:

Nicotine Helping Spur 'Prediabetes'

Provided By:

THURSDAY, June 11 (HealthDay News) -- The nicotine in cigarette smoke may promote insulin resistance and lead to a condition known as prediabetes, new research shows.

The finding, to be outlined Thursday at the Endocrine Society's annual meeting in Washington, D.C., could explain why smokers are at higher risk for diabetes. The same team of researchers was able to partially reverse nicotine's effect on insulin in mice by giving the rodents the nicotine-blunting drug mecamylamine.

In a society news release, study author Dr. Theodore Friedman, chief of the division of endocrinology, metabolism and molecular medicine at Charles R. Drew University of Medicine and Science in Los Angeles, noted that smokers tend to face a higher diabetes risk, even though "smoking causes weight loss, which should protect against heart disease."

But prior studies have shown smokers to be more insulin-resistant, which leads to higher blood-sugar levels. Some studies had suggested that the key factor at work was nicotine's effect on the stress hormone cortisol, since, as Friedman said, "cortisol excess is known to induce insulin resistance."

In their study, the team gave adult mice twice-daily injections of nicotine for 14 days. The mice displayed higher levels of cortisol in the blood. They also ate less and lost weight compared to mice that did not receive the shots but nonetheless developed insulin resistance and prediabetes.

Treating the mice with the nicotine-agonist drug mecamylamine blocked this process somewhat, the researchers noted.

"Our results suggest that reducing tissue glucocorticoid levels or decreasing insulin resistance may reduce the heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be drugs to specifically block the effect of nicotine on glucocorticoids [such as cortisol] and insulin resistance."

More information

There's more on prediabetes at the American Diabetes Association.

SOURCE: The Endocrine Society, news release, June 11, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com